The Binding of Isaac: Mods Ranked

An ordered list of my favourite content mods for The Binding of Isaac: Rebirth

Fiend Folio: Reheated A grand community-made expansion which adds hundreds of new foes, items, and rocks from people who've helped bring you Revelations, Retribution, The Devil's Harvest, Alphabirth, Septic Shock, and more? Workshop Page
Official Wiki
Isaac Guru
Martha of Bethany Inspired by the unused concept of Bethany in the Binding of Isaac: Antibirth, the elder sister of Bethany family is now here! Workshop Page
Isaac Guru
Boss Butch Adds 13 brand new bosses to kick your ass in unique and surprising ways! Workshop Page
Fall from Grace A floor expansion mod which adds alternative floors which can appear when traveling through the floors added in the Repentance DLC (the Mother path). Workshop Page
Samael Play as Samael, the angel of death. Workshop Page
Isaac Guru
Sewing Machine The Sewing Machine is a brand new machine which allows you to upgrade your familiars during a run ! Workshop Page
Isaac Guru
The Sheriff A new gunslinger character with a revolver and no time for tears. Workshop Page
Isaac Guru
Isaac Reshaken A content pack MOD that adds over 40 new high quality items, trinkets, consumables, and foes! Workshop Page
Sweet Halloween This mod adds 6 new candy consumables to the game, each with a random set of effects! On top of that, it also adds 7 items and 5 trinkets. Workshop Page
Isaac Guru
Retribution Retribution adds over 190 brand new items to the Binding of Isaac - ranging from a feeble axolotl to a familiar red chain. Workshop Page
Official Wiki
Virtue Items This mod adds 7 new items, each based off a heavenly virtue: Chastity, Temperance, Charity, Diligence, Kindness, Patience and Humility. Workshop Page
Isaac Guru
Restored Monsters Pack Forgotten enemies have returned to the basement! Restored Monsters Pack is a mod that adds enemies ranging from unused monsters left in Repentance to new enemies based of developer concepts Workshop Page
Gibs! Gibs has appeared in the Catacombs! Workshop Page
Last Judgement A major content mod which aims to restore thoughts, ideas, and concepts that were proposed during the development of the official Binding of Isaac: Repentance DLC. Ideas which been unseen until now have been repurposed, refurbished, or reimagined to fit with the game's current iteration, in a collaboration between developers who worked on the DLC and those who have worked on large content mods such as Fiend Folio or Fall from Grace. Workshop Page
Mastema In the Book of Jubilees, Mastema was a fallen angel who carried out punishments, tempted humans, and tested their faith, all under God’s permission. Now, he’s made his way to the basement for you to play as! Workshop Page
Andromeda Reach for the stars as Andromeda, a new character that revolves around Planetariums. Normally, Planetariums are rare and not usually worth skipping treasure rooms for, but Andromeda makes them much more worthwhile and easier to get. You’ll almost always be able find at least one during a run, sometimes even two or three. Workshop Page/a>